STABILITY OF RECONSTITUTED INDOCIDR P.D.A. (INDOMETHACIN SODIUM TRIHYDRATE). 468

Sodium quercetin-8-sulfonate trihydrate

The organic anion of the title compound, {[Na(C(15)H(9)O(10)S)(H(2)O)(2)]·H(2)O}(n) {systematic name: poly[[diaqua-[μ-2-(3,4-dihy-droxy-phen-yl)-3,5,7-trihy-droxy-4-oxo-4H-chromene-8-sulfon-ato]-sodium] monohydrate]}, has a nearly planar structure. The Na atom is six-coordinated by O atoms, two from water mol-ecules and four from the anion. The dihedral angle between the ring systems in the ani...

Ibuprofen vs indomethacin for treatment of PDA in preterm infants.

Forty preterm infants (<33 weeks) with respiratory distress syndrome (RDS) and echocardiographically confirmed PDA were randomly assigned at days 2 and 3 of life to receive either intravenous indomethacin in a dose of 0.2 mg/kg for three doses at 12 hourly intervals, or intravenous ibuprofen 10 mg/kg followed by two more doses of 5 mg/kg administered at 24 and 48 hours after the first dose. All...

Stability and microbiological properties of a new formulation of epoprostenol sodium when reconstituted and diluted

PURPOSE Epoprostenol, used for the treatment of pulmonary arterial hypertension (PAH), has a number of limitations related to its short half-life in aqueous solution. The aim of this study was to evaluate the stability and microbiological properties of a new formulation, namely epoprostenol sodium with arginine and mannitol excipients (epoprostenol AM; Veletri®; Actelion Pharmaceuticals Ltd, Al...

Impact of reconstituted cytosol on protein stability.

Protein stability is usually studied in simple buffered solutions, but most proteins function inside cells, where the heterogeneous and crowded environment presents a complex, nonideal system. Proteins are expected to behave differently under cellular crowding owing to two types of contacts: hard-core repulsions and weak, chemical interactions. The effect of hard-core repulsions is purely entro...

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